Ontology highlight
ABSTRACT:
SUBMITTER: Lonetti A
PROVIDER: S-EPMC7409321 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Lonetti Annalisa A Indio Valentina V Laginestra Maria Antonella MA Tarantino Giuseppe G Chiarini Francesca F Astolfi Annalisa A Bertuccio Salvatore N SN Martelli Alberto M AM Locatelli Franco F Pession Andrea A Masetti Riccardo R
Cancers 20200720 7
Pediatric acute myeloid leukemia (AML) is an aggressive malignancy with poor prognosis for which there are few effective targeted approaches, despite the numerous genetic alterations, including <i>MLL</i> gene rearrangements (<i>MLL</i>-r). The histone methyltransferase DOT1L is involved in supporting the proliferation of <i>MLL</i>-r cells, for which a target inhibitor, Pinometostat, has been evaluated in a clinical trial recruiting pediatric <i>MLL</i>-r leukemic patients. However, modest clin ...[more]