Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation.

ABSTRACT: Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment option for patients suffering from chemotherapy-refractory or relapsed hematological malignancies. The occurrence of morbidity and mortality after allo-HCT is still high. This is partly correlated with the immunological recovery of the T cell subsets, of which the dynamics and relations to complications are still poorly understood. Detailed information on T cell subset recovery is crucial to provide tools for better prediction and modulation of adverse events. Here, we review the current knowledge regarding CD4⁺ and CD8⁺ T cells, γδ T cells, iNKT cells, Treg cells, MAIT cells and naive and memory T cell reconstitution, as well as their relations to outcome, considering different

SUBMITTER: Dekker L 

PROVIDER: S-EPMC7409323 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature