Unknown

Dataset Information

0

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis.


ABSTRACT: In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

SUBMITTER: Tomko AM 

PROVIDER: S-EPMC7409346 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis.

Tomko Andrea M AM   Whynot Erin G EG   Ellis Lee D LD   Dupré Denis J DJ  

Cancers 20200721 7


In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display ant  ...[more]

Similar Datasets

| S-EPMC9784742 | biostudies-literature
| S-EPMC8497796 | biostudies-literature
| S-EPMC11660729 | biostudies-literature
| S-EPMC9600568 | biostudies-literature
| S-EPMC11249406 | biostudies-literature
| S-EPMC6441301 | biostudies-literature
| S-EPMC9306207 | biostudies-literature
| S-EPMC7968383 | biostudies-literature
| S-EPMC6651100 | biostudies-literature
| S-EPMC7819294 | biostudies-literature