LINC00441 promotes cervical cancer progression by modulating miR-450b-5p/RAB10 axis.

ABSTRACT:

Background

As one of the most common gynaecological malignant tumors, cervical cancer (CC) has become an important public health issue. Emerging evidence has revealed long non-coding RNAs (lncRNAs) are crucial regulators of biological functions in cancers, including CC. And the oncogenic role of LINC00441 has been verified in hepatocellular carcinoma (HCC). But the molecular mechanism and biological functions of LINC00441 in CC remain unknown.

Methods

qRT-PCR analysis detected the expression of genes in CC tissues or cells. CCK-8, colony formation, flow cytometry, transwell, western blot assays as well as animal studies were conducted to analyze the function of LINC00441 in CC. Luciferase reporter, RIP and RNA pull down assays were applied to verify the binding relations amo

SUBMITTER: Han H 

PROVIDER: S-EPMC7409438 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature