Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy.

ABSTRACT:

Background

Myocardial fibrosis is observed in multiple cardiac conditions including hypertension and aortic stenosis. Excessive fibrosis is associated with adverse clinical outcomes, but longitudinal human data regarding changes in left ventricular remodelling and fibrosis over time are sparse because of the slow progression, thereby making longitudinal studies challenging. The purpose of this study was to establish and characterize a mouse model to study the development and regression of left ventricular hypertrophy and myocardial fibrosis in response to increased blood pressure and to understand how these processes reverse remodel following normalisation of blood pressure.

Methods

We performed a longitudinal study with serial cardiovascular magnetic resonance (CMR) imaging

SUBMITTER: Kwiecinski J 

PROVIDER: S-EPMC7409657 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature