Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas.

ABSTRACT:

Background

Immunotherapies targeting glioblastoma (GBM) have led to significant improvements in patient outcomes. TOX is closely associated with the immune environment surrounding tumors, but its role in gliomas is not fully understood.

Methods

Using data from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), we analyzed the transcriptomes of 1691 WHO grade I-IV human glioma samples. The R language was used to perform most of the statistical analyses. Somatic mutations and somatic copy number variation (CNV) were analyzed using GISTIC 2.0.

Results

TOX was down-regulated in malignant gliomas compared to low grade gliomas, and upregulated in the proneural and IDH mutant subtypes of GBM. TOX^low tumours are associated with the loss of P

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7409670 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature