Timing of norepinephrine initiation in patients with septic shock: a systematic review and meta-analysis.

ABSTRACT:

Background

The effect of the timing of norepinephrine initiation on clinical outcomes in patients with septic shock is uncertain. A systematic review and meta-analysis was performed to evaluate the impact of early and late start of norepinephrine support on clinical outcomes in patients with septic shock.

Methods

We searched the PubMed, Cochrane, and Embase databases for randomized controlled trials (RCTs) and cohort studies from inception to the 1st of March 2020. We included studies involving adult patients (> 18 years) with septic shock. All authors reported our primary outcome of short-term mortality and clearly comparing early versus late norepinephrine initiation with clinically relevant secondary outcomes (ICU length of stay, time to achieved target mean arterial pres

SUBMITTER: Li Y 

PROVIDER: S-EPMC7409707 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature