Transcriptome profiling of pluripotent pig embryonic stem cells originating from uni- and biparental embryos.

ABSTRACT:

Objectives

Pig pluripotent stem cells have tremendous potential because the pig is a valuable animal as both an agricultural resource and as a preclinical model of human therapy. To date, a lack of understanding of pig pluripotency has inhibited the derivation of embryonic stem cells (ESCs) and transgene-free induced pluripotent stem cells. Therefore, there has been no accessible or reliable transcriptome data for researching the genuine pig pluripotency network. Our previous study isolated authentic pig ESCs, which had teratoma-forming and direct differentiation ability, that were derived by activating the FGF2, ACTIVIN A, and WNT pathways. Here, we aimed to provide detailed information on transcriptome data of the newly derived pig ESCs and perform a comparative analysis with pig

SUBMITTER: Choi KH 

PROVIDER: S-EPMC7409711 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature