Developments in the Histopathological Classification of ANCA-Associated Glomerulonephritis.

ABSTRACT:

Background and objectives

The histopathologic classification for ANCA-associated GN distinguishes four classes on the basis of patterns of injury. In the original validation study, these classes were ordered by severity of kidney function loss as follows: focal, crescentic, mixed, and sclerotic. Subsequent validation studies disagreed on outcomes in the crescentic and mixed classes. This study, driven by the original investigators, provides several analyses in order to determine the current position of the histopathologic classification of ANCA-associated GN.

Design, setting, participants, & measurements

A validation study was performed with newly collected data from 145 patients from ten centers worldwide, including an analysis of interobserver agreement on the histopatholo

SUBMITTER: van Daalen EE 

PROVIDER: S-EPMC7409752 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature