Comparative Efficacy and Safety of BP-Lowering Pharmacotherapy in Patients Undergoing Maintenance Dialysis: A Network Meta-Analysis of Randomized, Controlled Trials.

ABSTRACT:

Background and objectives

Elevated BP is an important risk factor for cardiovascular disease, with a prevalence of over 80% in patients undergoing maintenance dialysis. We assessed the comparative BP-lowering efficacy and the safety of BP-lowering drugs in patients undergoing maintenance dialysis.

Design, settings, participants, & measurements

We performed a frequentist random effects network meta-analysis of randomized, controlled trials evaluating BP-lowering agents in adult patients undergoing maintenance dialysis. Electronic databases (CENTRAL, MEDLINE, and Embase) were systematically searched (up to August 2018) for relevant trials. The main outcome was systolic BP reduction.

Results

Forty trials (4283 participants) met our inclusion criteria. Angiotensin-convert

SUBMITTER: Shaman AM 

PROVIDER: S-EPMC7409758 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature