Anti-COVID-19 multi-epitope vaccine designs employing global viral genome sequences.

ABSTRACT:

Background

The coronavirus SARS-CoV-2 is a member of the Coronaviridae family that has caused a global public health emergency. Currently, there is no approved treatment or vaccine available against it. The current study aimed to cover the diversity of SARS-CoV-2 strains reported from all over the world and to design a broad-spectrum multi-epitope vaccine using an immunoinformatics approach.

Methods

For this purpose, all available complete genomes were retrieved from GISAID and NGDC followed by genome multiple alignments to develop a global consensus sequence to compare with the reference genome. Fortunately, comparative genomics and phylogeny revealed a significantly high level of conservation between the viral strains. All the Open Reading Frames (ORFs) of the reference se

SUBMITTER: Zaheer T 

PROVIDER: S-EPMC7409810 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature