Obesogenic Memory Maintains Adipose Tissue Inflammation and Insulin Resistance.

ABSTRACT:

Background

Obesity is characterized by visceral adipose tissue (AT) inflammation. Immunosuppressive regulatory T cells (Tregs), phagocytic M2-like macrophages, and innate lymphoid cells type 2 (ILC2) control lean AT inflammation to maintain systemic insulin sensitivity, while the loss of these cells in obesity leads to AT inflammation and insulin resistance (IR).

Objective

The objective of this study was to determine if weight loss following obesity would correct AT inflammation and systemic metabolism.

Results

After six months of high fat diet (HFD) in male C57/Bl6 mice, flow analyses of epidydimal AT stromal vascular fraction (SVF) revealed depleted Tregs by 50%, doubling of CD8⁺ T cells, tripling of pro-inflammatory M1-like macrophages, and an 80% drop i

SUBMITTER: Blaszczak AM 

PROVIDER: S-EPMC7409818 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature