Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?

ABSTRACT: SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys₁₈₉-X-X-Cys₁₉₂-X _n -Cys₂₂₄-X-Cys₂₂₆) and a classic catalytic site (Cys₁₁₁-His₂₇₂-Asp₂₈₆), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication.

SUBMITTER: Maiti BK 

PROVIDER: S-EPMC7409920 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature