Immunoinformatic approach to assess SARS-CoV-2 protein S epitopes recognised by the most frequent MHC-I alleles in the Brazilian population.

ABSTRACT:

Aims

Brazil is nowadays one of the epicentres of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and new therapies are needed to face it. In the context of specific immune response against the virus, a correlation between Major Histocompatibility Complex Class I (MHC-I) and the severity of the disease in patients with COVID-19 has been suggested. Aiming at better understanding the biology of the infection and the immune response against the virus in the Brazilian population, we analysed SARS-CoV-2 protein S peptides in order to identify epitopes able to elicit an immune response mediated by the most frequent MHC-I alleles using in silico methods.

Methods

Our analyses consisted in searching for the most frequent Human Leukocyte Antigen (HLA)-A, HLA-B

SUBMITTER: Moura RR 

PROVIDER: S-EPMC7409971 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature