Ovarian estradiol supports sexual behavior but not energy homeostasis in female marmoset monkeys.

ABSTRACT:

Objective

In adult female rodents, ovarian estradiol (E₂) regulates body weight, adiposity, energy balance, physical activity, glucose-insulin homeodynamics, and lipid metabolism, while protecting against diet-induced obesity. The same E₂ actions are presumed to occur in primates, but confirmatory studies have been lacking.

Methods

We investigated the consequences of ovariectomy (OVX) and E₂ replacement in female marmoset monkeys on major metabolic and morphometric endpoints. Sexual behavior and uterine diameters were assessed as positive controls for E₂ treatment efficacy. Metabolic parameters were measured 1 mo prior to OVX, and 3 and 6 mo thereafter. During OVX, animals received empty or E₂-containing silastic s.c. im

SUBMITTER: Kraynak M 

PROVIDER: S-EPMC7410230 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature