Outcomes of decitabine treatment for newly diagnosed acute myeloid leukemia in older adults​.

ABSTRACT:

Purpose

We evaluated the outcomes of decitabine as first-line treatment in older patients with acute myeloid leukemia (AML) and investigated the predictors, including a baseline mini nutritional assessment short form (MNA-SF) score, of response and survival.

Patients and methods

Between 2010 and 2018, 96 AML patients aged 65 and above who received decitabine treatment at 6 centers in Korea were retrospectively evaluated. Response rates, hematologic improvements (HI), progression-free survival (PFS), and overall survival (OS) were analyzed.

Results

The median age at diagnosis was 73.9 years, and the median number of decitabine treatments administered to the patients was 4 (range, 1-29). Of 85 patients, 15 patients (17.6%) achieved complete remission (CR) or CR with inc

SUBMITTER: Yoo KH 

PROVIDER: S-EPMC7410295 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature