Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors.

ABSTRACT:

Background

Prior research has documented shared heritable contributions to non-suicidal self-injury (NSSI) and suicidal ideation (SI) as well as NSSI and suicide attempt (SA). In addition, trauma exposure has been implicated in risk for NSSI and suicide. Genetically informative studies are needed to determine common sources of liability to all three self-injurious thoughts and behaviors, and to clarify the nature of their associations with traumatic experiences.

Methods

Multivariate biometric modeling was conducted using data from 9526 twins [59% female, mean age = 31.7 years (range 24-42)] from two cohorts of the Australian Twin Registry, some of whom also participated in the Childhood Trauma Study and the Nicotine Addiction Genetics Project.

Results

The prevalences

SUBMITTER: Richmond-Rakerd LS 

PROVIDER: S-EPMC7410360 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature