Imaging Biomarkers of the Physis: Cartilage Volume on MRI vs. Tract Volume and Length on Diffusion Tensor Imaging.

ABSTRACT:

Background

Current methods to predict height and growth failure are imprecise. MRI measures of physeal cartilage are promising biomarkers for growth.

Purpose

In the physis, to assess how 3D MRI volume measurements, and diffusion tensor imaging (DTI) measurements (tract volume and length) correlate with growth parameters and detect differences in growth. We compared patients exposed to cis-retinoic acid, which causes physeal damage and growth failure, with normal subjects.

Study type

Case-control.

Population

Twenty pediatric neuroblastoma survivors treated with cis-retinoic acid and 20 age- and sex-matched controls.

Field strength/sequence

3T; DTI and 3D double-echo steady-state (DESS) sequences.

Assessment

On distal femoral MR studies, physeal 3D

SUBMITTER: Duong P 

PROVIDER: S-EPMC7410391 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature