Global reference mapping of human transcription factor footprints.

ABSTRACT: Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits¹, but it remains challenging to distinguish variants that affect regulatory function². Genomic DNase I footprinting enables the quantitative, nucleotide-resolution delineation of sites of transcription factor occupancy within native chromatin^3-6. However, only a small fraction of such sites have been precisely resolved on the human genome sequence⁶. Here, to enable comprehensive mapping of transcription factor footprints, we produced high-density DNase I cleavage maps from 243 human cell and tissue types and states and integrated these da

SUBMITTER: Vierstra J 

PROVIDER: S-EPMC7410829 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature