Differential Regulation of miRNA Profiles of Human Cells Experimentally Infected by Leishmania donovani Isolated From Indian Visceral Leishmaniasis and Post-Kala-Azar Dermal Leishmaniasis.

ABSTRACT: MicroRNAs are small ribonucleic acid that act as an important regulator of gene expression at the molecular level. However, there is no comparative data on the regulation of microRNAs (miRNAs) in visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL). In this current study, we compared the expression miRNA profile in host cells (G_THP), with VL strain (G_VL) and PKDL strain-infected host cell (G_PKDL). Normalized read count comparison between different conditions revealed that the miRNAs are indeed differentially expressed. In G_PKDL with respect to G_VL and G_THP, a total of 798 and 879 miRNAs were identified, out of which 349 and 518 are known miRNAs, respectively. Comparative analysis of changes in miRNA exp

SUBMITTER: Kumar A 

PROVIDER: S-EPMC7410929 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature