Calcium Sets the Clock in Ameloblasts.

ABSTRACT:

Background

Stromal interaction molecule 1 (STIM1) is one of the main components of the store operated Ca²⁺ entry (SOCE) signaling pathway. Individuals with mutated STIM1 present severely hypomineralized enamel characterized as amelogenesis imperfecta (AI) but the downstream molecular mechanisms involved remain unclear. Circadian clock signaling plays a key role in regulating the enamel thickness and mineralization, but the effects of STIM1-mediated AI on circadian clock are unknown.

Objectives

The aim of this study is to examine the potential links between SOCE and the circadian clock during amelogenesis.

Methods

We have generated mice with ameloblast-specific deletion of Stim1 (Stim1 ^fl/fl/Amelx-iCre^+/+

SUBMITTER: Said R 

PROVIDER: S-EPMC7411184 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature