Comparative microRNA Transcriptomes in Domestic Goats Reveal Acclimatization to High Altitude.

ABSTRACT: High-altitude acclimatization is a representative example of vertebrates' acclimatization to harsh and extreme environments. Previous studies reported sufficient evidence for a molecular genetic basis of high-altitude acclimatization, and genomic patterns of genetic variation among populations and species have been widely elucidated in recent years. However, understanding of the miRNA role in high-altitude acclimatization have lagged behind, especially in non-model species. To investigate miRNA expression alterations of goats that were induced by high-altitude stress, we performed comparative miRNA transcriptome analysis on six hypoxia-sensitive tissues (heart, kidney, liver, lung, skeletal muscle, and spleen) in two goat populations from distinct altitudes (600 and 3000 m). We obtained th

SUBMITTER: Feng S 

PROVIDER: S-EPMC7411263 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature