Vertebral Fractures in Individuals With Type 2 Diabetes: More Than Skeletal Complications Alone.

ABSTRACT:

Objective

We aimed to assess whether individuals with type 2 diabetes (T2D) have increased risk of vertebral fractures (VFs) and to estimate nonvertebral fracture and mortality risk among individuals with both prevalent T2D and VFs.

Research design and methods

A systematic PubMed search was performed to identify studies that investigated the relationship between T2D and VFs. Cohorts providing individual participant data (IPD) were also included. Estimates from published summary data and IPD cohorts were pooled in a random-effects meta-analysis. Multivariate Cox regression models were used to estimate nonvertebral fracture and mortality risk among individuals with T2D and VFs.

Results

Across 15 studies comprising 852,705 men and women, individuals with T2D had lower ri

SUBMITTER: Koromani F 

PROVIDER: S-EPMC7411280 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature