Predicted therapeutic targets for COVID-19 disease by inhibiting SARS-CoV-2 and its related receptors.

ABSTRACT: The SARS-CoV-2 causes severe pulmonary infectious disease with an exponential spread-ability. In the present research, we have tried to look into the molecular cause of disease, dealing with the development and spread of the coronavirus disease 2019 (COVID-19). Therefore, different approaches have investigated against disease development and infection in this research; First, We identified hsa-miR-1307-3p out of 1872 pooled microRNAs, as the best miRNA, with the highest affinity to SARS-CoV-2 genome and its related cell signaling pathways. Second, the findings presented that this miRNA had a considerable role in PI3K/Act, endocytosis, and type 2 diabetes, moreover, it may play a critical role in the prevention of GRP78 production and the virus entering, proliferation and development. Third

SUBMITTER: Balmeh N 

PROVIDER: S-EPMC7411426 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature