Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway.

ABSTRACT: A significant decrease in the expression of spinal microRNA‑29c (miR‑29c), which is responsible for the regulation of oxytocin receptor (OXTR) expression, was observed in nerve injury pain during childbirth. The present study investigates whether spinal miR‑29c could be a potential target for the treatment of pain, via the oxytocin (OT)‑γ‑aminobutyric acid (GABA) pathway. A spared nerve injury (SNI) rat model was established to induce neuropathic pain, simulating hyperalgesia. Spinal neurons were treated with OT to mimic the hormonal changes in the central nervous system after delivery. A change in the neuronal miniature inhibitory postsynaptic currents (mIPSCs) was observed in neurons, following the silencing of miR‑29c or OT treatment with or without OXTR antagonist. The Von‑Frey apparat

SUBMITTER: Li C 

PROVIDER: S-EPMC7411447 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature