Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment: A Randomized Clinical Trial.

ABSTRACT:

Importance

Observational studies have suggested that angiotensin receptor blockers are associated with a unique cognitive protection. It is unclear if this is due to reduced blood pressure (BP) or angiotensin receptors type 1 blockade.

Objective

To determine neurocognitive effects of candesartan vs lisinopril in older adults with mild cognitive impairment (MCI).

Design, setting, and participants

This randomized clinical trial included participants aged 55 years or older with MCI and hypertension. Individuals were withdrawn from prior antihypertensive therapy and randomized in a 1 to 1 ratio to candesartan or lisinopril from June 2014 to December 2018. Participants underwent cognitive assessments at baseline and at 6 and 12 months. Brain magnetic resonance images were

SUBMITTER: Hajjar I 

PROVIDER: S-EPMC7411539 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature