STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.

ABSTRACT: Immunity to fungal infections is mediated by cells of the innate and adaptive immune system including Th17 cells. Ca²⁺ influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca²⁺ channel ORAI1. We here identify patients with a novel mutation in STIM1 (p.L374P) that abolished Ca²⁺ influx and resulted in increased susceptibility to fungal and other infections. In mice, deletion of STIM1 in all immune cells enhanced susceptibility to mucosal C. albicans infection, whereas T cell-specific deletion of STIM1 impaired immunity to systemic C. albicans infection. STIM1 deletion impaired the production of Th17 cytokines essential for antifungal immunity and compromised the expression of genes in several metabolic pathw

SUBMITTER: Kahlfuss S 

PROVIDER: S-EPMC7411566 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature