The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer.

ABSTRACT: Cancers are one of the leading causes of deaths nowadays. The development of new treatment schemes for oncological diseases is an interesting direction in experimental medicine. Therefore, the evaluation of the influence of two alkaloids-piperlongumine (PL), sanguinarine (SAN) and their combination-on the basic life processes of the A549 cell line was considered reasonable. The aim was achieved by analyzing the cytotoxic effects of PL and SAN and their combination in the ratio of 4:1 on the induction of cell death, changes in the distribution of cell cycle phases, reorganization of cytoskeleton and metastatic potential of A549 cells. The versatility of the applied concentration ratio was evaluated in terms of other cancer cell lines: MCF-7, H1299 and HepG2. The results obtained from the MT

SUBMITTER: Halas-Wisniewska M 

PROVIDER: S-EPMC7411589 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature