Artificial Metalloenzymes: From Selective Chemical Transformations to Biochemical Applications.

ABSTRACT: Artificial metalloenzymes (ArMs) comprise a synthetic metal complex in a protein scaffold. ArMs display performances combining those of both homogeneous catalysts and biocatalysts. Specifically, ArMs selectively catalyze non-natural reactions and reactions inspired by nature in water under mild conditions. In the past few years, the construction of ArMs that possess a genetically incorporated unnatural amino acid and the directed evolution of ArMs have become of great interest in the field. Additionally, biochemical applications of ArMs have steadily increased, owing to the fact that compartmentalization within a protein scaffold allows the synthetic metal complex to remain functional in a sea of inactivating biomolecules. In this review, we present updates on: 1) the newly reported ArMs,

SUBMITTER: Himiyama T 

PROVIDER: S-EPMC7411666 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature