A New Insight into Coating's Formation Mechanism Between TiO₂ and Alendronate on Titanium Dental Implant.

ABSTRACT: Organophosphorus compounds, like bisphosphonates, drugs for treatment and prevention of bone diseases, have been successfully applied in recent years as bioactive and osseoinductive coatings on dental implants. An integrated experimental-theoretical approach was utilized in this study to clarify the mechanism of bisphosphonate-based coating formation on dental implant surfaces. Experimental validation of the alendronate coating formation on the titanium dental implant surface was carried out by X-ray photoelectron spectroscopy and contact angle measurements. Detailed theoretical simulations of all probable molecular implant surface/alendronate interactions were performed employing quantum chemical calculations at the density functional theory level. The calculated Gibbs free energies of (T

SUBMITTER: Petrovic Z 

PROVIDER: S-EPMC7411690 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature