Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures.

ABSTRACT: Bicelles have been intensively studied for use as drug delivery carriers and in biological studies, but their preparation with low-cost materials and via a simple process would allow their use for other purposes as well. Herein, bicelles were prepared through a semi-spontaneous method using a mixture of hydrogenated soybean lecithin (SL) and a nonionic surfactant, polyoxyethylene cholesteryl ether (ChEO10), and then we investigated the effect of composition and temperature on the structure of bicelles, which is important to design tailored systems. As the fraction of ChEO10 (XC) was increased, a bimodal particle size distribution with a small particle size of several tens of nanometers and a large particle size of several hundred nanometers was obtained, and only small particles were obser

SUBMITTER: Aramaki K 

PROVIDER: S-EPMC7412056 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature