Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi.

ABSTRACT: The presence of commensal bacteria enhances both acute and persistent infection of murine noroviruses. For several enteric viral pathogens, mechanisms by which these bacteria enhance infection involve direct interactions between the virus and bacteria. While it has been demonstrated that human noroviruses bind to a variety of commensal bacteria, it is not known if this is also true for murine noroviruses. The goal of this study was to characterize interactions between murine noroviruses and commensal bacteria and determine the impact of bacterial growth conditions, incubation temperature and time, on murine norovirus attachment to microbes that comprise the mammalian microbiome. We show that murine noroviruses bind directly to commensal bacteria and show similar patterns of attachment as h

SUBMITTER: Madrigal JL 

PROVIDER: S-EPMC7412252 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature