Spatially Resolved Correlation between Stiffness Increase and Actin Aggregation around Nanofibers Internalized in Living Macrophages.

ABSTRACT: Plasticity and functional diversity of macrophages play an important role in resisting pathogens invasion, tumor progression and tissue repair. At present, nanodrug formulations are becoming increasingly important to induce and control the functional diversity of macrophages. In this framework, the internalization process of nanodrugs is co-regulated by a complex interplay of biochemistry, cell physiology and cell mechanics. From a biophysical perspective, little is known about cellular mechanics' modulation induced by the nanodrug carrier's internalization. In this study, we used the polylactic-co-glycolic acid (PLGA)-polyethylene glycol (PEG) nanofibers as a model drug carrier, and we investigated their influence on macrophage mechanics. Interestingly, the nanofibers internalized in macr

SUBMITTER: Zhou G 

PROVIDER: S-EPMC7412258 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature