Mortality in gastro-oesophageal reflux disease in a population-based nationwide cohort study of Swedish twins.

ABSTRACT:

Objectives

The public health disorder gastro-oesophageal reflux disease (GORD) is linked with several comorbidities, including oesophageal adenocarcinoma (OAC), but whether life expectancy is reduced by GORD is uncertain. This study assessed all-cause and cancer-specific mortality in GORD after controlling for confounding by heredity and other factors.

Design

Population-based cohort study from 1998 to 2015.

Setting

Swedish nationwide study.

Participants

Twins (n=40 961) born in 1958 or earlier in Sweden.

Exposure

GORD symptoms reported in structured computer-assisted telephone interviews.

Outcomes

The primary outcome was all-cause mortality and the secondary outcome was cancer-specific mortality among twins with GORD and twins without GORD. HRs an

SUBMITTER: Ness-Jensen E 

PROVIDER: S-EPMC7412590 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature