Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development.

ABSTRACT:

Background

4-vinylcyclohexene diepoxide (VCD) has long been considered a hazardous occupational chemical that promotes ovarian failure. However, VCD is also used as a research compound to chemically induce animal models of premature ovarian insufficiency (POI), and in related work we unexpectedly found that VCD apparently exhibits both dose- and duration-dependent opposing, hormone-like effects on the maintenance of the primordial follicle pool, follicle development, and ovulation induction.

Results

We conducted experiments with cultured murine ovaries and performed transplantation experiments using postnatal day (PD) 2 and PD12 mice and found that low-dose, short-term exposure to VCD (VCD^low) actually protects the primordial/primary follicle pool and improves the

SUBMITTER: Cao LB 

PROVIDER: S-EPMC7412635 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature