Overexpression of pyruvate dehydrogenase phosphatase 1 promotes the progression of pancreatic adenocarcinoma by regulating energy-related AMPK/mTOR signaling.

ABSTRACT:

Background

Human pyruvate dehydrogenase phosphatase 1 (PDP1) plays an important physiological role in energy metabolism; however, its expression and function in human pancreatic adenocarcinoma (PDAC) remain unknown. This study aimed to investigate the expression pattern and mechanisms of action of PDP1 in human PDAC.

Methods

The expression pattern of PDP1 in PDAC was determined, and its correlation with patient survival was analyzed. Ectopic expression or knockdown of PDP1 was performed, and in vitro proliferation and migration, as well as in vivo tumor growth of PDAC, were measured. The mechanism was studied by biochemical approaches.

Results

PDP1 was overexpressed in human PDAC samples, and high expression of PDP1 correlated with poor overall and disease-free surviv

SUBMITTER: Li Y 

PROVIDER: S-EPMC7412669 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature