Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis.

ABSTRACT: Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family. It has multiple effects on development, physiology and diseases. However, the role of GDF11 in the development of mesenchymal stem cells (MSCs) is not clear. To explore the effects of GDF11 on the differentiation and pro-angiogenic activities of MSCs, mouse bone marrow-derived MSCs were engineered to overexpress GDF11 (MSC^GDF11 ) and their capacity for differentiation and paracrine actions were examined both in vitro and in vivo. Expression of endothelial markers CD31 and VEGFR2 at the levels of both mRNA and protein was significantly higher in MSC^GDF11 than control MSCs (MSC^Vector ) during differentiation. More tube formation was observed in MSC^GDF11

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7412688 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature