PD-L1 Is Expressed and Promotes the Expansion of Regulatory T Cells in Acute Myeloid Leukemia.

ABSTRACT: Intratumoral accumulation of CD4⁺CD25⁺Foxp3⁺ regulatory T (Treg) cells occurs in acute myeloid leukemia (AML), but little is known about the role of tumor cells themselves in this process. Here, we showed that an immune checkpoint PD-L1 expressed by AML cells promoted the conversion and expansion of Treg cells sustaining high expression of Foxp3 and PD-1 as well as a suppressive function. Furthermore, an AML cell line HEL overexpressed PD-L1 promoted the conversion and expansion of Treg cells and CD4⁺PD-1⁺Foxp3⁺ T (PD-1⁺Treg) cells from the conventional CD4⁺ T cells. CD4⁺CD25^highPD-1⁺ T cells secreted more IL-10 production than CD4⁺CD25^highPD-1

SUBMITTER: Dong Y 

PROVIDER: S-EPMC7412746 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature