Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.

ABSTRACT:

Background

Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated morphologic and molecular changes in the peripheral lung of patients who die from Covid-19.

Methods

We examined 7 lungs obtained during autopsy from patients who died from Covid-19 and compared them with 7 lungs obtained during autopsy from patients who died from acute respiratory distress syndrome (ARDS) secondary to influenza A(H1N1) infection and 10 age-matched, uninfected control lungs. The lungs were studied with the use of seven-color immunohistochemical analysis, micro-computed tomographic imaging, scanning electron microscopy, cor

SUBMITTER: Ackermann M 

PROVIDER: S-EPMC7412750 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature