An interventional image-guided microdevice implantation and retrieval method for in-vivo drug response assessment.

ABSTRACT:

Purpose

Recently developed implantable microdevices can perform multi-drug response assessment of cancer drugs in-vivo, with potential to develop highly optimized personalized cancer treatment strategies. However, minimally invasive/interventional image-guided methods of in-vivo microdevice implantation, securement, and retrieval are needed for broad clinical translation. Here we demonstrate proof-of-concept of an interventional microdevice implantation and retrieval method for personalized drug response assessment, using ex-vivo phantom, ex-vivo tissue, and in-vivo murine models.

Methods

A method for minimally-invasive microdevice implantation and retrieval was developed, by which a custom-prototyped 6 mm retrievable microdevice can be implanted into a live tumor, deliver d

SUBMITTER: Bhagavatula SK 

PROVIDER: S-EPMC7412767 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature