Bismuth chelate as a contrast agent for X-ray computed tomography.

ABSTRACT:

Backgrounds

Due to the unexpected side effects of the iodinated contrast agents, novel contrast agents for X-ray computed tomography (CT) imaging are urgently needed. Nanoparticles made by heavy metal elements are often employed, such as gold and bismuth. These nanoparticles have the advantages of long in vivo circulation time and tumor targeted ability. However, due to the long residence time in vivo, these nanoparticles may bring unexpected toxicity and, the preparation methods of these nanoparticles are complicated and time-consuming.

Methods

In this investigation, a small molecular bismuth chelate using diethylenetriaminepentaacetic acid (DPTA) as the chelating agent was proposed to be an ideal CT contrast agent.

Results

The preparation method is easy and cost-eff

SUBMITTER: Fu JJ 

PROVIDER: S-EPMC7412782 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature