Atorvastatin promotes bone formation in aged apoE^-/- mice through the Sirt1-Runx2 axis.

ABSTRACT:

Background

Statins are the most widely used drugs in elderly patients; the most common clinical application of statins is in aged hyperlipemia patients. There are few studies on the effects and mechanisms of statins on bone in elderly mice with hyperlipemia. The study is to examine the effects of atorvastatin on bone phenotypes and metabolism in aged apolipoprotein E-deficient (apoE^-/-) mice, and the possible mechanisms involved in these changes.

Methods

Twenty-four 60-week-old apoE^-/- mice were randomly allocated to two groups. Twelve mice were orally gavaged with atorvastatin (10 mg/kg body weight/day) for 12 weeks; the others served as the control group. Bone mass and skeletal microarchitecture were determined using micro-CT. Bone metabolism was asse

SUBMITTER: Hong W 

PROVIDER: S-EPMC7412819 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature