ALDH3B1 Is an Independent Prognostic Biomarker of Lung Adenocarcinoma.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death, and adenocarcinoma is the most common type of lung cancer. Although emerging evidence implicates the role of several aldehyde dehydrogenases in cancer progression, the expression and clinical significance of aldehyde dehydrogenase 3B1 in lung adenocarcinoma has never been studied.

Materials

In our study, the expression of aldehyde dehydrogenase 3B1 in 250 cases of lung adenocarcinoma was detected with immunohistochemistry, and the patients were further divided into subgroups with different aldehyde dehydrogenase 3B1 expression. Using real-time polymerase chain reaction, we investigated the aldehyde dehydrogenase 3B1 messenger RNA in 20 lung adenocarcinoma and paired normal lung tissues. With the χ²

SUBMITTER: Sun H 

PROVIDER: S-EPMC7412899 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature