OBAMA: OBAMA for Bayesian amino-acid model averaging.

ABSTRACT:

Background

Bayesian analyses offer many benefits for phylogenetic, and have been popular for analysis of amino acid alignments. It is necessary to specify a substitution and site model for such analyses, and often an ad hoc, or likelihood based method is employed for choosing these models that are typically of no interest to the analysis overall.

Methods

We present a method called OBAMA that averages over substitution models and site models, thus letting the data inform model choices and taking model uncertainty into account. It uses trans-dimensional Markov Chain Monte Carlo (MCMC) proposals to switch between various empirical substitution models for amino acids such as Dayhoff, WAG, and JTT. Furthermore, it switches base frequencies from these substitution models or use ba

SUBMITTER: Bouckaert RR 

PROVIDER: S-EPMC7413081 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature