Ontology highlight
ABSTRACT:
SUBMITTER: Feng Z
PROVIDER: S-EPMC7413147 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Cell reports. Physical science 20200701 7
Intracellular protein filaments are ubiquitous for cellular functions, but forming bona fide biomimetic intracellular filaments of small molecules in living cells remains elusive. Here, we report the <i>in situ</i> formation of self-limiting intracellular filaments of a small peptide via enzymatic morphological transition of a phosphorylated and trimethylated heterochiral tetrapeptide. Enzymatic dephosphorylation reduces repulsive intermolecular electrostatic interactions and converts the peptid ...[more]