Midlife Smaller and Larger Infarctions, White Matter Hyperintensities, and 20-Year Cognitive Decline: A Cohort Study.

ABSTRACT:

Background

Smaller (<3-mm) infarctions are associated with stroke and stroke mortality, but relationships with cognitive decline are unknown.

Objective

To characterize the relationships of smaller, larger, and both smaller and larger infarctions in middle age with 20-year cognitive decline.

Design

Longitudinal cohort study.

Setting

Two ARIC (Atherosclerosis Risk in Communities) study sites with magnetic resonance imaging data (1993 to 1995) and up to 5 cognitive assessments over 20 years.

Participants

Stroke-free participants aged 50 years or older.

Measurements

Infarctions were categorized as none, smaller only, larger only (3 to 20 mm), or both smaller and larger. Global cognitive Z scores were derived from 3 cognitive tests administered up to 5

SUBMITTER: Windham BG 

PROVIDER: S-EPMC7413210 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature