Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders.

ABSTRACT: How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret the pathogenicity of noncoding variation. Here, we study histone modifications across thirteen tissues during human organogenesis. We integrate the data with transcription to build an overview of how the human genome differentially regulates alternative organ fates including by repression. Promoters from nearly 20,000 genes partition into discrete states. Key developmental gene sets are actively repressed outside of the appropriate organ without obvious bivalency. Candidate enhancers, functional in zebrafish, allow imputation of tissue-specific and shared pat

SUBMITTER: Gerrard DT 

PROVIDER: S-EPMC7413392 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature