Hepatitis B virus prevalence and vaccine antibody titers in children HIV exposed but uninfected in Botswana.

ABSTRACT:

Background

Botswana introduced the HBV vaccine at birth for all newborns in 2000. To the best of our knowledge, since the introduction of HBV vaccination, there have been limited data for vaccine response to HBV and its impact on early childhood HBV infections among children HIV exposed but uninfected in Botswana.

Aims

To determine the prevalence of hepatitis B surface antigen (HBsAg) and HBV vaccine response in 18 months old children HIV exposed but uninfected in Botswana.

Methods

Stored plasma samples from 304 children at 18 months of age and 287 mothers from delivery were tested for HBsAg. Mothers with positive HBsAg had HBV DNA level tested, and their HBV genotypes were determined by amplifying a 415-base pair (bp) region of the surface gene. Plasma samples from c

SUBMITTER: Baruti K 

PROVIDER: S-EPMC7413399 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature