Major bleeding risk and mortality associated with antiplatelet drugs in real-world clinical practice. A prospective cohort study.

ABSTRACT:

Background

Major bleedings other than gastrointestinal (GI) and intracranial (ICH) and mortality rates associated with antiplatelet drugs in real-world clinical practice are unknown. The objective was to estimate major bleeding risk and mortality among new users of antiplatelet drugs in real-world clinical practice.

Methods and findings

A population-based prospective cohort using the French national health data system (SNIIRAM), identified 69,911 adults living within five well-defined geographical areas, who were new users of antiplatelet drugs in 2013-2015 and who had not received any antithrombotics in 2012. Among them, 63,600 started a monotherapy and 6,311 a dual regimen. Clinical data for all adults referred for bleeding was collected from all emergency departments with

SUBMITTER: Bouget J 

PROVIDER: S-EPMC7413418 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature