Comparison of different calculation techniques for absorbed dose assessment in patient specific peptide receptor radionuclide therapy.

ABSTRACT:

Aim

The present work concerns the comparison of the performances of three systems for dosimetry in RPT that use different techniques for absorbed dose calculation (organ-level dosimetry, voxel-level dose kernel convolution and Monte Carlo simulations). The aim was to assess the importance of the choice of the most adequate calculation modality, providing recommendations about the choice of the computation tool.

Methods

The performances were evaluated both on phantoms and patients in a multi-level approach. Different phantoms filled with a 177Lu-radioactive solution were used: a homogeneous cylindrical phantom, a phantom with organ-shaped inserts and two cylindrical phantoms with inserts different for shape and volume. A total of 70 patients with NETs treated by PRRT with 177

SUBMITTER: Finocchiaro D 

PROVIDER: S-EPMC7413508 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature